Malaria Vaccine Trial
Description
Volunteer patients were randomized into one of two experiment groups where they would receive an experimental vaccine or a placebo. They were subsequently exposed to a drug-sensitive strain of malaria and observed to see whether they came down with an infection.
Usage
malaria
Format
A data frame with 20 observations on the following 2 variables.
- treatment
Whether a person was given the experimental
vaccineor aplacebo.- outcome
Whether the person got an
infectionorno infection.
Details
In this study, volunteer patients were randomized into one of two experiment groups: 14 patients received an experimental vaccine or 6 patients received a placebo vaccine. Nineteen weeks later, all 20 patients were exposed to a drug-sensitive malaria virus strain; the motivation of using a drug-sensitive strain of virus here is for ethical considerations, allowing any infections to be treated effectively.
Source
Lyke et al. 2017. PfSPZ vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection. PNAS 114(10):2711-2716. \Sexpr[results=rd,stage=build]{tools:::Rd_expr_doi("10.1073/pnas.1615324114")}.